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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SET All Species: 40.91
Human Site: T180 Identified Species: 69.23
UniProt: Q01105 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q01105 NP_001116293.1 290 33489 T180 W K S G K D L T K R S S Q T Q
Chimpanzee Pan troglodytes XP_001159448 829 93320 K180 W K S G K E R K L L A A A Q Q
Rhesus Macaque Macaca mulatta XP_001110579 290 33486 T180 W K S G K D L T K R S S Q T Q
Dog Lupus familis XP_851207 289 33547 T179 W K S G K D L T K R S S Q T Q
Cat Felis silvestris
Mouse Mus musculus Q9EQU5 289 33359 T179 W K S G K D L T K R S S Q T Q
Rat Rattus norvegicus Q63945 289 33387 T179 W K S G K D L T K R S S Q T Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518746 289 33461 T179 W K S G K D L T K R S S Q T Q
Chicken Gallus gallus NP_001025862 277 32133 T167 W K S G K D L T K R S S Q T Q
Frog Xenopus laevis NP_001084174 278 32182 T167 W K A G K D L T K R S S Q T Q
Zebra Danio Brachydanio rerio NP_958876 275 31780 T167 W K A G K D L T K R T G Q T P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P53997 269 30976 K168 T S T P I K W K E G K N L L K
Honey Bee Apis mellifera XP_001120556 314 35895 T168 W K E G A D L T K R A K T K A
Nematode Worm Caenorhab. elegans Q18240 312 35855 F166 K E N K K P P F P E D G D S A
Sea Urchin Strong. purpuratus XP_001175529 322 36489 T172 W K P N K D L T K G N L S G N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 30.5 99.6 96.2 N.A. 94.1 94.1 N.A. 86.5 88.6 86.2 83.7 N.A. 57.9 52.2 33.9 55.5
Protein Similarity: 100 33.2 99.6 96.2 N.A. 95.8 95.8 N.A. 87.9 90 90 89.6 N.A. 74.1 70.6 53.8 70.1
P-Site Identity: 100 40 100 100 N.A. 100 100 N.A. 100 100 93.3 73.3 N.A. 0 53.3 6.6 46.6
P-Site Similarity: 100 60 100 100 N.A. 100 100 N.A. 100 100 100 86.6 N.A. 26.6 60 26.6 53.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 15 0 8 0 0 0 0 0 15 8 8 0 15 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 79 0 0 0 0 8 0 8 0 0 % D
% Glu: 0 8 8 0 0 8 0 0 8 8 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 79 0 0 0 0 0 15 0 15 0 8 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 8 86 0 8 86 8 0 15 79 0 8 8 0 8 8 % K
% Leu: 0 0 0 0 0 0 79 0 8 8 0 8 8 8 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 8 8 0 0 0 0 0 0 8 8 0 0 8 % N
% Pro: 0 0 8 8 0 8 8 0 8 0 0 0 0 0 8 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 65 8 65 % Q
% Arg: 0 0 0 0 0 0 8 0 0 72 0 0 0 0 0 % R
% Ser: 0 8 58 0 0 0 0 0 0 0 58 58 8 8 0 % S
% Thr: 8 0 8 0 0 0 0 79 0 0 8 0 8 65 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 86 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _